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Silica-encapsulated benzoyl peroxide improved acne more with less skin irritation than a conventional form of the medication, according to results of a randomized clinical trial.
Two different strengths of silica-encapsulated drug significantly reduced lesion counts compared with nonencapsulated therapy, Daniela Mavor, of Sol Gel Technologies in Ness Ziona, Israel, reported at the International Congress of Dermatology.
Differences in efficacy and tolerability emerged early and persisted through the study.
“As early as week two, we noted a reduction of acne lesions, which was significantly superior to leading commercial products,” Stanley Shapiro, Ph.D., also of Sol Gel, said in a statement. “At week four, a 75% improvement was achieved.
“Throughout the study, the high-strength acne kits were significantly better tolerated than the two commercial products,” he said.
Benzoyl peroxide is an established therapy for acne, but the compound often causes burning and irritation that ranges from mild to severe. Read the rest of this entry »
Tags: acne, acne lesions, acne medication, Acne Vulgaris, Active Ingredient, benzoyl peroxide, Continuous Release, Daniela Mavor, Delivery Vehicle, Inflammatory Lesions, International Congress, Investigator Global Assessment, irritation, Israel, Lesion, moderate acne, Ness Ziona, Poster Presentation, Randomized Clinical Trial, Silica, Skin Irritation, Sol Gel, Sol Gel Technologies, Stanley Shapiro, Study Participants, Treatment Groups

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